Pyrilutamide (KX-826) is a non-steroidal anti-androgen that works by blocking testosterone and DHT from binding to the androgen receptor. It is being developed by Kintor Pharmaceutical and is currently in Phase II clinical trials for androgenetic alopecia in the US and China.
PyriPure is a pure pyrilutamide solution in a propylene glycol and ethanol vehicle. Each batch is tested and confirmed >99% pure by a 3rd party.
How to Buy
Buy Pyrilutamide, also known as KX-826, is a potential first-in-class small molecule AR antagonist the Kintor Pharmaceuticals Group is developing for the treatment of androgenetic alopecia. The Group completed phase Ib clinical trials for the topical gel formulation of pyrilutamide in male androgenic alopecia subjects in August 2020 and is currently undertaking phase II studies for the same indication in China.
Kintor’s pyrilutamide gel formula is based on Ru58841, an antiandrogen that inhibits testosterone and DHT from binding to androgen receptors in hair follicles. The topical solution is available as PyriPure and comes in a propylene glycol and ethanol vehicle. PyriPure is tested and confirmed >99% pure by a 3rd party.
PyriPure is packaged in an air and light tight bottle, and comes with a calibrated dropper.
Pyrilutamide (development code KX826) is a topical androgen receptor antagonist that has shown some promise in early clinical trials for hair loss. The 0.5% solution is applied once a day in the scalp as a tincture or gel. It is well tolerated in the trials that have been conducted. The most common side effect is contact dermatitis but this typically improves easily and quickly.
The drug is being developed by Kintor Pharmaceutical which has other research projects in the pipeline as well. They are working on an anti-androgen GT20029 that is an AR-PROTAC compound that can inhibit androgens while still allowing normal cell functions.
They are also working on a ketone ester prodrug that may have similar effects. In fact, some people who didn’t get results with finasteride or RU 58841 have been hopeful that this could be the savior they are looking for. Kintor has already started a phase III trial for the compound in China.
Pyrilutamide is an androgen receptor antagonist that binds to and blocks the androgen receptor. It is believed that it may be useful in treating androgenetic alopecia. Kintor Pharmaceutical, a company that is focused on researching and developing new treatments for hair loss, has recently published a press release in which they discussed their phase 2 China trial results for pyrilutamide.
It is possible that the US FDA will accept these results as proof of efficacy, although it would still have to pass a phase 3 clinical trial. Kintor also has another new compound in development called GT20029, which is an AR-PROTAC drug and is likely to be used to treat both alopecia and acne.
The phase 2 US trial will be a randomized, double-blind, vehicle-controlled study with a sample size of over 400 men. It is expected to measure the change from baseline in non-vellus target area hair counts over a 6 month period. The resulting data should provide important information regarding the effectiveness and safety of pyrilutamide as an alternative to finasteride.
Buy Pyrilutamide in Europe is a drug that has been in the works for some time now and it looks like it could finally be available next year (2021). Kintor, who owns this drug has dual trials going on in both the US and China with pyrilutamide for hair loss.
In the US, they are testing pyrilutamide in a placebo controlled trial and in the China trial, they are using an active medication known as GT200029 which is an AR-PROTAC. They are also planning a phase 3 trial for both the US and China based off the results of this study.
Pyrilutamide is a molecule that binds to the androgen receptor with a high affinity. It was once developed to treat acne but has shown promising results for androgenetic alopecia as well. Many people who can’t use finasteride or RU58841 hope that this new treatment will be their savior. Anecdotal reports have been mixed and there are some guys who have claimed to have great results but others have reported no growth or even thinning after using it.